L-Hyoscyamine Free Base
Brand names,
L-Hyoscyamine Free Base
Analogs
L-Hyoscyamine Free Base
Brand Names Mixture
L-Hyoscyamine Free Base
Chemical_Formula
C17H23NO3
L-Hyoscyamine Free Base
RX_link
http://www.rxlist.com/cgi/generic/hyoscy.htm
L-Hyoscyamine Free Base
fda sheet
L-Hyoscyamine Free Base
msds (material safety sheet)
L-Hyoscyamine Free Base
Synthesis Reference
Fodor et al., Acta Chem. Acad. Sci. Hung.28(4), 409 (1961)
L-Hyoscyamine Free Base
Molecular Weight
289.369 g/mol
L-Hyoscyamine Free Base
Melting Point
141oC
L-Hyoscyamine Free Base
H2O Solubility
3.56 mg/mL
L-Hyoscyamine Free Base
State
Solid
L-Hyoscyamine Free Base
LogP
2.904
L-Hyoscyamine Free Base
Dosage Forms
Tablets; Oral drops; Elixir; Injection
L-Hyoscyamine Free Base
Indication
For treatment of bladder spasms, peptic ulcer disease, diverticulitis, colic, irritable bowel syndrome, cystitis, and pancreatitis. Also used to treat certain heart conditions, to control the symptoms of Parkinson's disease and rhinitis.
L-Hyoscyamine Free Base
Pharmacology
L-Hyoscyamine, the active optical isomer of atropine (dl-hyoscyamine), is a tertiary amine anticholinergic gastrointestinal agent.
L-Hyoscyamine Free Base
Absorption
Absorbed totally and completely by sublingual administration as well as oral administration.
L-Hyoscyamine Free Base
side effects and Toxicity
Symptoms of overdose include headache, nausea, vomiting, blurred vision, dilated pupils, hot dry skin, dizziness, dryness of the mouth, difficulty in swallowing, and CNS stimulation. LD50=mg/kg(orally in rat)
L-Hyoscyamine Free Base
Patient Information
L-Hyoscyamine Free Base
Organisms Affected
Humans and other mammals