Intropin

Intropin Brand names, Intropin Analogs

Intropin Brand Names Mixture

No information avaliable

Intropin Chemical_Formula

C₈H₁₁NO₂

Intropin RX_link

http://www.rxlist.com/cgi/generic3/dopamine.htm

Intropin fda sheet

Intropin msds (material safety sheet)

Intropin MSDS

Intropin Synthesis Reference

No information avaliable

Intropin Molecular Weight

153.178 g/mol

Intropin Melting Point

82.5 ^oC

Intropin H₂O Solubility

600 g/L

Intropin State

Solid

Intropin LogP

0.548

Intropin Dosage Forms

Solution

Intropin Indication

For the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure

Intropin Pharmacology

Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings.

Intropin Absorption

Dopamine is rapidly absorbed from the small intestine.

Intropin side effects and Toxicity

LD₅₀ oral mice = 1460 mg/kg, LD₅₀ oral rats = 1780 mg/kg. Spasm or closing of eyelids, nausea, vomiting, cardiac arrhythmias, involuntary movements of the body including the face, tongue, arms, hand, head, and upper body; hypotension, haemolytic anaemia, urinary retention, duodenal ulcer, sialorrhea, ataxia, abdominal pain, dry mouth, nightmares, tachypnoea, bruxism, confusion, and insomnia.

Intropin Patient Information