Ifenec
Brand names,
Ifenec
Analogs
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Brand Names Mixture
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Chemical_Formula
C12H15N5O3
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RX_link
http://www.rxlist.com/cgi/generic4/baraclude.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
277.279 g/mol
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Melting Point
No information avaliable
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H2O Solubility
Slightly soluble (2.4 mg/mL at pH 7.9, 25oC)
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State
Solid
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LogP
No information avaliable
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Dosage Forms
Film-coated tablets for oral administration (0.5 mg, 1 mg); Oral solution (0.05 mg/mL)
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Indication
For the treatment of chronic hepatitis B virus infection in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
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Pharmacology
Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV). It is designed to selectively inhibit the Hepatitis B virus, blocking all three steps in the replication process. Entecavir is more efficient than an older Hepatitis B drug, lamivudine.
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Absorption
Absorption Following oral administration in healthy subjects, entecavir peak plasma concentrations occurred between 0.5 and 1.5 hours. In healthy subjects, the bioavailability of the tablet is 100% relative to the oral solution.
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side effects and Toxicity
No information avaliable
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Patient Information
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Organisms Affected
Hepatitis B