Gemfibrozil
Gemfibrozil Brand names, Gemfibrozil Analogs
Gemfibrozil Brand Names Mixture
- No information avaliable
Gemfibrozil Chemical_Formula
C15H22O3
Gemfibrozil RX_link
http://www.rxlist.com/cgi/generic/gemfib.htm
Gemfibrozil fda sheet
Gemfibrozil msds (material safety sheet)
Gemfibrozil Synthesis Reference
P. L. CREGER, U.S. Pat. 3,674,836 (1972)
Gemfibrozil Molecular Weight
250.333 g/mol
Gemfibrozil Melting Point
61-63 oC
Gemfibrozil H2O Solubility
10 mg/mL (in base)
Gemfibrozil State
Solid
Gemfibrozil LogP
4.242
Gemfibrozil Dosage Forms
Tablets; Capsules
Gemfibrozil Indication
For treatment of adult patients with very high elevations of serum triglyceride levels (types IV and V hyperlipidemia) who are at risk of developing pancreatitis (inflammation of the pancreas) and who do not respond adequately to a strict diet.
Gemfibrozil Pharmacology
Gemfibrozil, a fibric acid antilipemic agent similar to clofibrate, is used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia. It acts to reduce triglyceride levels, reduce VLDL levels, reduce LDL levels (moderately), and increase HDL levels (moderately).
Gemfibrozil Absorption
Well absorbed from gastrointestinal tract (within 1-2 hours).
Gemfibrozil side effects and Toxicity
Oral, mouse: LD50 = 3162 mg/kg. Symptoms of overdose include abdominal cramps, diarrhea, joint and muscle pain, nausea, and vomiting.
Gemfibrozil Patient Information
Gemfibrozil is used to lower high triglyceride and cholesterol levels. Notify your physician if you are pregnant or nursing. Gemfibrozil should be taken 30 minutes before the morning and evening meals. This medication may cause dizziness or blurred vision; use caution while driving or operating hazardous machinery. Gemfibrozil may cause an increase in blood sugar. If you have diabetes mellitus, carefully monitor blood sugar levels. Notify your physician if you develop severe stomach pain, muscle pain or weakness, or unexplained fever.
Gemfibrozil Organisms Affected
Humans and other mammals
