Lopid
Lopid Brand names, Lopid Analogs
Lopid Brand Names Mixture
- No information avaliable
Lopid Chemical_Formula
C15H22O3
Lopid RX_link
http://www.rxlist.com/cgi/generic/gemfib.htm
Lopid fda sheet
Lopid msds (material safety sheet)
Lopid Synthesis Reference
P. L. CREGER, U.S. Pat. 3,674,836 (1972)
Lopid Molecular Weight
250.333 g/mol
Lopid Melting Point
61-63 oC
Lopid H2O Solubility
10 mg/mL (in base)
Lopid State
Solid
Lopid LogP
4.242
Lopid Dosage Forms
Tablets; Capsules
Lopid Indication
For treatment of adult patients with very high elevations of serum triglyceride levels (types IV and V hyperlipidemia) who are at risk of developing pancreatitis (inflammation of the pancreas) and who do not respond adequately to a strict diet.
Lopid Pharmacology
Gemfibrozil, a fibric acid antilipemic agent similar to clofibrate, is used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia. It acts to reduce triglyceride levels, reduce VLDL levels, reduce LDL levels (moderately), and increase HDL levels (moderately).
Lopid Absorption
Well absorbed from gastrointestinal tract (within 1-2 hours).
Lopid side effects and Toxicity
Oral, mouse: LD50 = 3162 mg/kg. Symptoms of overdose include abdominal cramps, diarrhea, joint and muscle pain, nausea, and vomiting.
Lopid Patient Information
Gemfibrozil is used to lower high triglyceride and cholesterol levels. Notify your physician if you are pregnant or nursing. Gemfibrozil should be taken 30 minutes before the morning and evening meals. This medication may cause dizziness or blurred vision; use caution while driving or operating hazardous machinery. Gemfibrozil may cause an increase in blood sugar. If you have diabetes mellitus, carefully monitor blood sugar levels. Notify your physician if you develop severe stomach pain, muscle pain or weakness, or unexplained fever.
Lopid Organisms Affected
Humans and other mammals
