Novo-Gemfibrozil
Brand names,
Novo-Gemfibrozil
Analogs
Novo-Gemfibrozil
Brand Names Mixture
Novo-Gemfibrozil
Chemical_Formula
C15H22O3
Novo-Gemfibrozil
RX_link
http://www.rxlist.com/cgi/generic/gemfib.htm
Novo-Gemfibrozil
fda sheet
Novo-Gemfibrozil
msds (material safety sheet)
Novo-Gemfibrozil
Synthesis Reference
P. L. CREGER, U.S. Pat. 3,674,836 (1972)
Novo-Gemfibrozil
Molecular Weight
250.333 g/mol
Novo-Gemfibrozil
Melting Point
61-63 oC
Novo-Gemfibrozil
H2O Solubility
10 mg/mL (in base)
Novo-Gemfibrozil
State
Solid
Novo-Gemfibrozil
LogP
4.242
Novo-Gemfibrozil
Dosage Forms
Tablets; Capsules
Novo-Gemfibrozil
Indication
For treatment of adult patients with very high elevations of serum triglyceride levels (types IV and V hyperlipidemia) who are at risk of developing pancreatitis (inflammation of the pancreas) and who do not respond adequately to a strict diet.
Novo-Gemfibrozil
Pharmacology
Gemfibrozil, a fibric acid antilipemic agent similar to clofibrate, is used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia. It acts to reduce triglyceride levels, reduce VLDL levels, reduce LDL levels (moderately), and increase HDL levels (moderately).
Novo-Gemfibrozil
Absorption
Well absorbed from gastrointestinal tract (within 1-2 hours).
Novo-Gemfibrozil
side effects and Toxicity
Oral, mouse: LD50 = 3162 mg/kg. Symptoms of overdose include abdominal cramps, diarrhea, joint and muscle pain, nausea, and vomiting.
Novo-Gemfibrozil
Patient Information
Gemfibrozil is used to lower high triglyceride and cholesterol levels. Notify your physician if you are pregnant
or nursing. Gemfibrozil should be taken 30 minutes before the morning and evening meals. This medication may cause
dizziness or blurred vision; use caution while driving or operating hazardous machinery. Gemfibrozil may cause an
increase in blood sugar. If you have diabetes mellitus, carefully monitor blood sugar levels. Notify your physician
if you develop severe stomach pain, muscle pain or weakness, or unexplained fever.
Novo-Gemfibrozil
Organisms Affected
Humans and other mammals