Gen-Fibro
Gen-Fibro Brand names, Gen-Fibro Analogs
Gen-Fibro Brand Names Mixture
- No information avaliable
Gen-Fibro Chemical_Formula
C15H22O3
Gen-Fibro RX_link
http://www.rxlist.com/cgi/generic/gemfib.htm
Gen-Fibro fda sheet
Gen-Fibro msds (material safety sheet)
Gen-Fibro Synthesis Reference
P. L. CREGER, U.S. Pat. 3,674,836 (1972)
Gen-Fibro Molecular Weight
250.333 g/mol
Gen-Fibro Melting Point
61-63 oC
Gen-Fibro H2O Solubility
10 mg/mL (in base)
Gen-Fibro State
Solid
Gen-Fibro LogP
4.242
Gen-Fibro Dosage Forms
Tablets; Capsules
Gen-Fibro Indication
For treatment of adult patients with very high elevations of serum triglyceride levels (types IV and V hyperlipidemia) who are at risk of developing pancreatitis (inflammation of the pancreas) and who do not respond adequately to a strict diet.
Gen-Fibro Pharmacology
Gemfibrozil, a fibric acid antilipemic agent similar to clofibrate, is used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia. It acts to reduce triglyceride levels, reduce VLDL levels, reduce LDL levels (moderately), and increase HDL levels (moderately).
Gen-Fibro Absorption
Well absorbed from gastrointestinal tract (within 1-2 hours).
Gen-Fibro side effects and Toxicity
Oral, mouse: LD50 = 3162 mg/kg. Symptoms of overdose include abdominal cramps, diarrhea, joint and muscle pain, nausea, and vomiting.
Gen-Fibro Patient Information
Gemfibrozil is used to lower high triglyceride and cholesterol levels. Notify your physician if you are pregnant or nursing. Gemfibrozil should be taken 30 minutes before the morning and evening meals. This medication may cause dizziness or blurred vision; use caution while driving or operating hazardous machinery. Gemfibrozil may cause an increase in blood sugar. If you have diabetes mellitus, carefully monitor blood sugar levels. Notify your physician if you develop severe stomach pain, muscle pain or weakness, or unexplained fever.
Gen-Fibro Organisms Affected
Humans and other mammals
