Lipur
Lipur Brand names, Lipur Analogs
Lipur Brand Names Mixture
- No information avaliable
Lipur Chemical_Formula
C15H22O3
Lipur RX_link
http://www.rxlist.com/cgi/generic/gemfib.htm
Lipur fda sheet
Lipur msds (material safety sheet)
Lipur Synthesis Reference
P. L. CREGER, U.S. Pat. 3,674,836 (1972)
Lipur Molecular Weight
250.333 g/mol
Lipur Melting Point
61-63 oC
Lipur H2O Solubility
10 mg/mL (in base)
Lipur State
Solid
Lipur LogP
4.242
Lipur Dosage Forms
Tablets; Capsules
Lipur Indication
For treatment of adult patients with very high elevations of serum triglyceride levels (types IV and V hyperlipidemia) who are at risk of developing pancreatitis (inflammation of the pancreas) and who do not respond adequately to a strict diet.
Lipur Pharmacology
Gemfibrozil, a fibric acid antilipemic agent similar to clofibrate, is used to treat hyperlipoproteinemia and as a second-line therapy for type IIb hypercholesterolemia. It acts to reduce triglyceride levels, reduce VLDL levels, reduce LDL levels (moderately), and increase HDL levels (moderately).
Lipur Absorption
Well absorbed from gastrointestinal tract (within 1-2 hours).
Lipur side effects and Toxicity
Oral, mouse: LD50 = 3162 mg/kg. Symptoms of overdose include abdominal cramps, diarrhea, joint and muscle pain, nausea, and vomiting.
Lipur Patient Information
Gemfibrozil is used to lower high triglyceride and cholesterol levels. Notify your physician if you are pregnant or nursing. Gemfibrozil should be taken 30 minutes before the morning and evening meals. This medication may cause dizziness or blurred vision; use caution while driving or operating hazardous machinery. Gemfibrozil may cause an increase in blood sugar. If you have diabetes mellitus, carefully monitor blood sugar levels. Notify your physician if you develop severe stomach pain, muscle pain or weakness, or unexplained fever.
Lipur Organisms Affected
Humans and other mammals
