Dopamine

Dopamine Brand names, Dopamine Analogs

Dopamine Brand Names Mixture

No information avaliable

Dopamine Chemical_Formula

C₈H₁₁NO₂

Dopamine RX_link

http://www.rxlist.com/cgi/generic3/dopamine.htm

Dopamine fda sheet

Dopamine msds (material safety sheet)

Dopamine MSDS

Dopamine Synthesis Reference

No information avaliable

Dopamine Molecular Weight

153.178 g/mol

Dopamine Melting Point

82.5 ^oC

Dopamine H₂O Solubility

600 g/L

Dopamine State

Solid

Dopamine LogP

0.548

Dopamine Dosage Forms

Solution

Dopamine Indication

For the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure

Dopamine Pharmacology

Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings.

Dopamine Absorption

Dopamine is rapidly absorbed from the small intestine.

Dopamine side effects and Toxicity

LD₅₀ oral mice = 1460 mg/kg, LD₅₀ oral rats = 1780 mg/kg. Spasm or closing of eyelids, nausea, vomiting, cardiac arrhythmias, involuntary movements of the body including the face, tongue, arms, hand, head, and upper body; hypotension, haemolytic anaemia, urinary retention, duodenal ulcer, sialorrhea, ataxia, abdominal pain, dry mouth, nightmares, tachypnoea, bruxism, confusion, and insomnia.

Dopamine Patient Information