Dirgotarl
Brand names,
Dirgotarl
Analogs
Dirgotarl
Brand Names Mixture
Dirgotarl
Chemical_Formula
C33H37N5O5
Dirgotarl
RX_link
http://www.rxlist.com/cgi/generic2/dihyergmes.htm
Dirgotarl
fda sheet
Dirgotarl
msds (material safety sheet)
Dirgotarl
Synthesis Reference
No information avaliable
Dirgotarl
Molecular Weight
583.678 g/mol
Dirgotarl
Melting Point
No information avaliable
Dirgotarl
H2O Solubility
No information avaliable
Dirgotarl
State
Solid
Dirgotarl
LogP
No information avaliable
Dirgotarl
Dosage Forms
Liquid
Dirgotarl
Indication
For the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes.
Dirgotarl
Pharmacology
Dihydroergotamine is indicated for the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes. Dihydroergotamine binds with high affinity to 5-HT1Da and 5-HT1Db receptors. It also binds with high affinity to serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors, noradrenaline a2A, a2B and a receptors, and dopamine D2L and D3 receptors. The therapeutic activity of Dihydroergotamine in migraine is generally attributed to the agonist effect at 5-HT1D receptors.
Dirgotarl
Absorption
Interpatient variable and may be dependent on the administration technique
Dirgotarl
side effects and Toxicity
Side effects include abdominal pain, abnormal speech, coma, confusion, convulsions, hallucinations, increase and/or decrease in blood pressure, nausea, numbness, tingling, pain, and a bluish color of your fingersand toes, slowed breathing, vomiting
Dirgotarl
Patient Information
PATIENT INFORMATIOn
Follow the link below to get detailed information before taking D.H.E. 45� (dihydroergotamine mesylate) Injection.
http://www.rxlist.com/cgi/generic2/dihyergmes_pi.htm
Dirgotarl
Organisms Affected
Humans and other mammals