Dihydergot
Brand names,
Dihydergot
Analogs
Dihydergot
Brand Names Mixture
Dihydergot
Chemical_Formula
C33H37N5O5
Dihydergot
RX_link
http://www.rxlist.com/cgi/generic2/dihyergmes.htm
Dihydergot
fda sheet
Dihydergot
msds (material safety sheet)
Dihydergot
Synthesis Reference
No information avaliable
Dihydergot
Molecular Weight
583.678 g/mol
Dihydergot
Melting Point
No information avaliable
Dihydergot
H2O Solubility
No information avaliable
Dihydergot
State
Solid
Dihydergot
LogP
No information avaliable
Dihydergot
Dosage Forms
Liquid
Dihydergot
Indication
For the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes.
Dihydergot
Pharmacology
Dihydroergotamine is indicated for the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes. Dihydroergotamine binds with high affinity to 5-HT1Da and 5-HT1Db receptors. It also binds with high affinity to serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors, noradrenaline a2A, a2B and a receptors, and dopamine D2L and D3 receptors. The therapeutic activity of Dihydroergotamine in migraine is generally attributed to the agonist effect at 5-HT1D receptors.
Dihydergot
Absorption
Interpatient variable and may be dependent on the administration technique
Dihydergot
side effects and Toxicity
Side effects include abdominal pain, abnormal speech, coma, confusion, convulsions, hallucinations, increase and/or decrease in blood pressure, nausea, numbness, tingling, pain, and a bluish color of your fingersand toes, slowed breathing, vomiting
Dihydergot
Patient Information
PATIENT INFORMATIOn
Follow the link below to get detailed information before taking D.H.E. 45� (dihydroergotamine mesylate) Injection.
http://www.rxlist.com/cgi/generic2/dihyergmes_pi.htm
Dihydergot
Organisms Affected
Humans and other mammals