DHE-45
Brand names,
DHE-45
Analogs
DHE-45
Brand Names Mixture
DHE-45
Chemical_Formula
C33H37N5O5
DHE-45
RX_link
http://www.rxlist.com/cgi/generic2/dihyergmes.htm
DHE-45
fda sheet
DHE-45
msds (material safety sheet)
DHE-45
Synthesis Reference
No information avaliable
DHE-45
Molecular Weight
583.678 g/mol
DHE-45
Melting Point
No information avaliable
DHE-45
H2O Solubility
No information avaliable
DHE-45
State
Solid
DHE-45
LogP
No information avaliable
DHE-45
Dosage Forms
Liquid
DHE-45
Indication
For the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes.
DHE-45
Pharmacology
Dihydroergotamine is indicated for the acute treatment of migraine headaches with or without aura and the acute treatment of cluster headache episodes. Dihydroergotamine binds with high affinity to 5-HT1Da and 5-HT1Db receptors. It also binds with high affinity to serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors, noradrenaline a2A, a2B and a receptors, and dopamine D2L and D3 receptors. The therapeutic activity of Dihydroergotamine in migraine is generally attributed to the agonist effect at 5-HT1D receptors.
DHE-45
Absorption
Interpatient variable and may be dependent on the administration technique
DHE-45
side effects and Toxicity
Side effects include abdominal pain, abnormal speech, coma, confusion, convulsions, hallucinations, increase and/or decrease in blood pressure, nausea, numbness, tingling, pain, and a bluish color of your fingersand toes, slowed breathing, vomiting
DHE-45
Patient Information
PATIENT INFORMATIOn
Follow the link below to get detailed information before taking D.H.E. 45� (dihydroergotamine mesylate) Injection.
http://www.rxlist.com/cgi/generic2/dihyergmes_pi.htm
DHE-45
Organisms Affected
Humans and other mammals