Diphenhydrinate
Brand names,
Diphenhydrinate
Analogs
Diphenhydrinate
Brand Names Mixture
Diphenhydrinate
Chemical_Formula
C17H22N2O
Diphenhydrinate
RX_link
No information avaliable
Diphenhydrinate
fda sheet
Diphenhydrinate
msds (material safety sheet)
Diphenhydrinate
Synthesis Reference
No information avaliable
Diphenhydrinate
Molecular Weight
270.369 g/mol
Diphenhydrinate
Melting Point
< 25 oC
Diphenhydrinate
H2O Solubility
1 g/ml (succinate salt)
Diphenhydrinate
State
Liquid
Diphenhydrinate
LogP
2.755
Diphenhydrinate
Dosage Forms
Tablet for oral administration
Diphenhydrinate
Indication
Used alone as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug. Also used in combination with Vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.
Diphenhydrinate
Pharmacology
Doxylamine is an antihistamine commonly used as a sleep aid. This drug is also used to relieve symptoms of hay fever (allergic rhinitis), hives (rash or itching), and other allergic reactions. Doxylamine is a member of the ethanolamine class of antihistamines and has anti-allergy power far superior to virtually every other antihistamine on the market, with the exception of diphenhydramine (Benadryl). It is also the most powerful over-the-counter sedative available in the United States, and more sedating than many prescription hypnotics. In a study, it was found to be superior to even the barbiturate, phenobarbital for use as a sedative. Doxylamine is also a potent anticholinergic.
Diphenhydrinate
Absorption
Readily absorbed via the gastrointestinal tract.
Diphenhydrinate
side effects and Toxicity
Signs of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, swelling of face, lips, tongue, or throat.
Diphenhydrinate
Patient Information
No information avaliable
Diphenhydrinate
Organisms Affected
Humans and other mammals