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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C17H22N2O
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
270.369 g/mol
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Melting Point
< 25 oC
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H2O Solubility
1 g/ml (succinate salt)
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State
Liquid
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LogP
2.755
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Dosage Forms
Tablet for oral administration
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Indication
Used alone as a short-term sleep aid, in combination with other drugs as a night-time cold and allergy relief drug. Also used in combination with Vitamin B6 (pyridoxine) to prevent morning sickness in pregnant women.
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Pharmacology
Doxylamine is an antihistamine commonly used as a sleep aid. This drug is also used to relieve symptoms of hay fever (allergic rhinitis), hives (rash or itching), and other allergic reactions. Doxylamine is a member of the ethanolamine class of antihistamines and has anti-allergy power far superior to virtually every other antihistamine on the market, with the exception of diphenhydramine (Benadryl). It is also the most powerful over-the-counter sedative available in the United States, and more sedating than many prescription hypnotics. In a study, it was found to be superior to even the barbiturate, phenobarbital for use as a sedative. Doxylamine is also a potent anticholinergic.
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Absorption
Readily absorbed via the gastrointestinal tract.
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side effects and Toxicity
Signs of overdose include wheezing, tightness in the chest, fever, itching, bad cough, blue skin color, fits, swelling of face, lips, tongue, or throat.
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals