Diazoxide
Diazoxide Brand names, Diazoxide Analogs
Diazoxide Brand Names Mixture
- No information avaliable
Diazoxide Chemical_Formula
C8H7ClN2O2S
Diazoxide RX_link
No information avaliable
Diazoxide fda sheet
Diazoxide msds (material safety sheet)
Diazoxide Synthesis Reference
No information avaliable
Diazoxide Molecular Weight
230.672 g/mol
Diazoxide Melting Point
330.5 oC
Diazoxide H2O Solubility
2850 mg/L
Diazoxide State
Solid
Diazoxide LogP
2.135
Diazoxide Dosage Forms
Oral capsules; Oral suspension
Diazoxide Indication
Used parentally to treat hypertensive emergencies. Also used to treat hypoglycemia secondary to insulinoma.
Diazoxide Pharmacology
Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.
Diazoxide Absorption
Readily absorbed following oral administration.
Diazoxide side effects and Toxicity
Oral LD50 in rat and mouse: 980 mg/kg and 444 mg/kg, respectively.
Diazoxide Patient Information
No information avaliable
Diazoxide Organisms Affected
Humans and other mammals
