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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C8H7ClN2O2S
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
230.672 g/mol
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Melting Point
330.5 oC
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H2O Solubility
2850 mg/L
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State
Solid
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LogP
2.135
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Dosage Forms
Oral capsules; Oral suspension
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Indication
Used parentally to treat hypertensive emergencies. Also used to treat hypoglycemia secondary to insulinoma.
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Pharmacology
Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.
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Absorption
Readily absorbed following oral administration.
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side effects and Toxicity
Oral LD50 in rat and mouse: 980 mg/kg and 444 mg/kg, respectively.
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals