Proglycem
Brand names,
Proglycem
Analogs
Proglycem
Brand Names Mixture
Proglycem
Chemical_Formula
C8H7ClN2O2S
Proglycem
RX_link
No information avaliable
Proglycem
fda sheet
Proglycem
msds (material safety sheet)
Proglycem
Synthesis Reference
No information avaliable
Proglycem
Molecular Weight
230.672 g/mol
Proglycem
Melting Point
330.5 oC
Proglycem
H2O Solubility
2850 mg/L
Proglycem
State
Solid
Proglycem
LogP
2.135
Proglycem
Dosage Forms
Oral capsules; Oral suspension
Proglycem
Indication
Used parentally to treat hypertensive emergencies. Also used to treat hypoglycemia secondary to insulinoma.
Proglycem
Pharmacology
Diazoxide is a potassium channel activator, which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. This switches off voltage-gated calcium ion channels which inhibits the generation of an action potential.
Proglycem
Absorption
Readily absorbed following oral administration.
Proglycem
side effects and Toxicity
Oral LD50 in rat and mouse: 980 mg/kg and 444 mg/kg, respectively.
Proglycem
Patient Information
No information avaliable
Proglycem
Organisms Affected
Humans and other mammals