DOPA

DOPA Brand names, DOPA Analogs

DOPA Brand Names Mixture

No information avaliable

DOPA Chemical_Formula

C₈H₁₁NO₂

DOPA RX_link

http://www.rxlist.com/cgi/generic3/dopamine.htm

DOPA fda sheet

DOPA msds (material safety sheet)

DOPA MSDS

DOPA Synthesis Reference

No information avaliable

DOPA Molecular Weight

153.178 g/mol

DOPA Melting Point

82.5 ^oC

DOPA H₂O Solubility

600 g/L

DOPA State

Solid

DOPA LogP

0.548

DOPA Dosage Forms

Solution

DOPA Indication

For the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure

DOPA Pharmacology

Dopamine is a natural catecholamine formed by the decarboxylation of 3,4-dihydroxyphenylalanine (DOPA). It is a precursor to norepinephrine in noradrenergic nerves and is also a neurotransmitter in certain areas of the central nervous system, especially in the nigrostriatal tract, and in a few peripheral sympathetic nerves. Dopamine produces positive chronotropic and inotropic effects on the myocardium, resulting in increased heart rate and cardiac contractility. This is accomplished directly by exerting an agonist action on beta-adrenoceptors and indirectly by causing release of norepinephrine from storage sites in sympathetic nerve endings.

DOPA Absorption

Dopamine is rapidly absorbed from the small intestine.

DOPA side effects and Toxicity

LD₅₀ oral mice = 1460 mg/kg, LD₅₀ oral rats = 1780 mg/kg. Spasm or closing of eyelids, nausea, vomiting, cardiac arrhythmias, involuntary movements of the body including the face, tongue, arms, hand, head, and upper body; hypotension, haemolytic anaemia, urinary retention, duodenal ulcer, sialorrhea, ataxia, abdominal pain, dry mouth, nightmares, tachypnoea, bruxism, confusion, and insomnia.

DOPA Patient Information