Colistin
Colistin Brand names, Colistin Analogs
Colistin Brand Names Mixture
- No information avaliable
Colistin Chemical_Formula
C52H98N16O13
Colistin RX_link
No information avaliable
Colistin fda sheet
Colistin msds (material safety sheet)
Colistin Synthesis Reference
No information avaliable
Colistin Molecular Weight
2797.3193 g/mol
Colistin Melting Point
200 - 220 oC
Colistin H2O Solubility
5.64E+005 mg/L
Colistin State
Solid
Colistin LogP
-4.648
Colistin Dosage Forms
Capsule; Cream; Liquid; Ointment; Powder for solution; Solution; Suspension; Tablet; Tablet (enteric-coated); Tablet (extended-release)
Colistin Indication
For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.
Colistin Pharmacology
Colistin is a polymyxin antibiotic agent. Polymyxins are cationic polypeptides that disrupt the bacterial cell membrane through a detergentlike mechanism. With the development of less toxic agents, such as extended-spectrum penicillins and cephalosporins, parenteral polymyxin use was largely abandoned, except for the treatment of multidrug-resistant pulmonary infections in patients with cystic fibrosis. More recently, however, the emergence of multidrug-resistant gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, and the lack of new antimicrobial agents have led to the revived use of the polymyxins.
Colistin Absorption
Very poor absorption from gastrointestinal tract.
Colistin side effects and Toxicity
Oral LD50 in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.
Colistin Patient Information
No information avaliable
Colistin Organisms Affected
Gram-negative bacilli
