Gecophen
Gecophen Brand names, Gecophen Analogs
Gecophen Brand Names Mixture
- No information avaliable
Gecophen Chemical_Formula
C52H98N16O13
Gecophen RX_link
No information avaliable
Gecophen fda sheet
Gecophen msds (material safety sheet)
Gecophen Synthesis Reference
No information avaliable
Gecophen Molecular Weight
2797.3193 g/mol
Gecophen Melting Point
200 - 220 oC
Gecophen H2O Solubility
5.64E+005 mg/L
Gecophen State
Solid
Gecophen LogP
-4.648
Gecophen Dosage Forms
Capsule; Cream; Liquid; Ointment; Powder for solution; Solution; Suspension; Tablet; Tablet (enteric-coated); Tablet (extended-release)
Gecophen Indication
For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.
Gecophen Pharmacology
Colistin is a polymyxin antibiotic agent. Polymyxins are cationic polypeptides that disrupt the bacterial cell membrane through a detergentlike mechanism. With the development of less toxic agents, such as extended-spectrum penicillins and cephalosporins, parenteral polymyxin use was largely abandoned, except for the treatment of multidrug-resistant pulmonary infections in patients with cystic fibrosis. More recently, however, the emergence of multidrug-resistant gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, and the lack of new antimicrobial agents have led to the revived use of the polymyxins.
Gecophen Absorption
Very poor absorption from gastrointestinal tract.
Gecophen side effects and Toxicity
Oral LD50 in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.
Gecophen Patient Information
No information avaliable
Gecophen Organisms Affected
Gram-negative bacilli
