PharmacyCodes



p-Chlorophenyl en es it fr

p-Chlorophenyl Brand names, p-Chlorophenyl Analogs

p-Chlorophenyl Brand Names Mixture

  • No information avaliable

p-Chlorophenyl Chemical_Formula

C52H98N16O13

p-Chlorophenyl RX_link

No information avaliable

p-Chlorophenyl fda sheet

p-Chlorophenyl msds (material safety sheet)

p-Chlorophenyl MSDS

p-Chlorophenyl Synthesis Reference

No information avaliable

p-Chlorophenyl Molecular Weight

2797.3193 g/mol

p-Chlorophenyl Melting Point

200 - 220 oC

p-Chlorophenyl H2O Solubility

5.64E+005 mg/L

p-Chlorophenyl State

Solid

p-Chlorophenyl LogP

-4.648

p-Chlorophenyl Dosage Forms

Capsule; Cream; Liquid; Ointment; Powder for solution; Solution; Suspension; Tablet; Tablet (enteric-coated); Tablet (extended-release)

p-Chlorophenyl Indication

For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.

p-Chlorophenyl Pharmacology

Colistin is a polymyxin antibiotic agent. Polymyxins are cationic polypeptides that disrupt the bacterial cell membrane through a detergentlike mechanism. With the development of less toxic agents, such as extended-spectrum penicillins and cephalosporins, parenteral polymyxin use was largely abandoned, except for the treatment of multidrug-resistant pulmonary infections in patients with cystic fibrosis. More recently, however, the emergence of multidrug-resistant gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, and the lack of new antimicrobial agents have led to the revived use of the polymyxins.

p-Chlorophenyl Absorption

Very poor absorption from gastrointestinal tract.

p-Chlorophenyl side effects and Toxicity

Oral LD50 in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.

p-Chlorophenyl Patient Information

No information avaliable

p-Chlorophenyl Organisms Affected

Gram-negative bacilli