PharmacyCodes



alpha-Glyceryl ether en es it fr

alpha-Glyceryl ether Brand names, alpha-Glyceryl ether Analogs

alpha-Glyceryl ether Brand Names Mixture

  • No information avaliable

alpha-Glyceryl ether Chemical_Formula

C52H98N16O13

alpha-Glyceryl ether RX_link

No information avaliable

alpha-Glyceryl ether fda sheet

alpha-Glyceryl ether msds (material safety sheet)

alpha-Glyceryl_ether MSDS

alpha-Glyceryl ether Synthesis Reference

No information avaliable

alpha-Glyceryl ether Molecular Weight

2797.3193 g/mol

alpha-Glyceryl ether Melting Point

200 - 220 oC

alpha-Glyceryl ether H2O Solubility

5.64E+005 mg/L

alpha-Glyceryl ether State

Solid

alpha-Glyceryl ether LogP

-4.648

alpha-Glyceryl ether Dosage Forms

Capsule; Cream; Liquid; Ointment; Powder for solution; Solution; Suspension; Tablet; Tablet (enteric-coated); Tablet (extended-release)

alpha-Glyceryl ether Indication

For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.

alpha-Glyceryl ether Pharmacology

Colistin is a polymyxin antibiotic agent. Polymyxins are cationic polypeptides that disrupt the bacterial cell membrane through a detergentlike mechanism. With the development of less toxic agents, such as extended-spectrum penicillins and cephalosporins, parenteral polymyxin use was largely abandoned, except for the treatment of multidrug-resistant pulmonary infections in patients with cystic fibrosis. More recently, however, the emergence of multidrug-resistant gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, and the lack of new antimicrobial agents have led to the revived use of the polymyxins.

alpha-Glyceryl ether Absorption

Very poor absorption from gastrointestinal tract.

alpha-Glyceryl ether side effects and Toxicity

Oral LD50 in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.

alpha-Glyceryl ether Patient Information

No information avaliable

alpha-Glyceryl ether Organisms Affected

Gram-negative bacilli