Gechophen
Gechophen Brand names, Gechophen Analogs
Gechophen Brand Names Mixture
- No information avaliable
Gechophen Chemical_Formula
C52H98N16O13
Gechophen RX_link
No information avaliable
Gechophen fda sheet
Gechophen msds (material safety sheet)
Gechophen Synthesis Reference
No information avaliable
Gechophen Molecular Weight
2797.3193 g/mol
Gechophen Melting Point
200 - 220 oC
Gechophen H2O Solubility
5.64E+005 mg/L
Gechophen State
Solid
Gechophen LogP
-4.648
Gechophen Dosage Forms
Capsule; Cream; Liquid; Ointment; Powder for solution; Solution; Suspension; Tablet; Tablet (enteric-coated); Tablet (extended-release)
Gechophen Indication
For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.
Gechophen Pharmacology
Colistin is a polymyxin antibiotic agent. Polymyxins are cationic polypeptides that disrupt the bacterial cell membrane through a detergentlike mechanism. With the development of less toxic agents, such as extended-spectrum penicillins and cephalosporins, parenteral polymyxin use was largely abandoned, except for the treatment of multidrug-resistant pulmonary infections in patients with cystic fibrosis. More recently, however, the emergence of multidrug-resistant gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, and the lack of new antimicrobial agents have led to the revived use of the polymyxins.
Gechophen Absorption
Very poor absorption from gastrointestinal tract.
Gechophen side effects and Toxicity
Oral LD50 in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.
Gechophen Patient Information
No information avaliable
Gechophen Organisms Affected
Gram-negative bacilli
