Maolate
Maolate Brand names, Maolate Analogs
Maolate Brand Names Mixture
- No information avaliable
Maolate Chemical_Formula
C52H98N16O13
Maolate RX_link
No information avaliable
Maolate fda sheet
Maolate msds (material safety sheet)
Maolate Synthesis Reference
No information avaliable
Maolate Molecular Weight
2797.3193 g/mol
Maolate Melting Point
200 - 220 oC
Maolate H2O Solubility
5.64E+005 mg/L
Maolate State
Solid
Maolate LogP
-4.648
Maolate Dosage Forms
Capsule; Cream; Liquid; Ointment; Powder for solution; Solution; Suspension; Tablet; Tablet (enteric-coated); Tablet (extended-release)
Maolate Indication
For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.
Maolate Pharmacology
Colistin is a polymyxin antibiotic agent. Polymyxins are cationic polypeptides that disrupt the bacterial cell membrane through a detergentlike mechanism. With the development of less toxic agents, such as extended-spectrum penicillins and cephalosporins, parenteral polymyxin use was largely abandoned, except for the treatment of multidrug-resistant pulmonary infections in patients with cystic fibrosis. More recently, however, the emergence of multidrug-resistant gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, and the lack of new antimicrobial agents have led to the revived use of the polymyxins.
Maolate Absorption
Very poor absorption from gastrointestinal tract.
Maolate side effects and Toxicity
Oral LD50 in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.
Maolate Patient Information
No information avaliable
Maolate Organisms Affected
Gram-negative bacilli
