PharmacyCodes



Chlorophenesin en es it fr

Chlorophenesin Brand names, Chlorophenesin Analogs

Chlorophenesin Brand Names Mixture

  • No information avaliable

Chlorophenesin Chemical_Formula

C52H98N16O13

Chlorophenesin RX_link

No information avaliable

Chlorophenesin fda sheet

Chlorophenesin msds (material safety sheet)

Chlorophenesin MSDS

Chlorophenesin Synthesis Reference

No information avaliable

Chlorophenesin Molecular Weight

2797.3193 g/mol

Chlorophenesin Melting Point

200 - 220 oC

Chlorophenesin H2O Solubility

5.64E+005 mg/L

Chlorophenesin State

Solid

Chlorophenesin LogP

-4.648

Chlorophenesin Dosage Forms

Capsule; Cream; Liquid; Ointment; Powder for solution; Solution; Suspension; Tablet; Tablet (enteric-coated); Tablet (extended-release)

Chlorophenesin Indication

For the treatment of acute or chronic infections due to sensitive strains of certain gram-negative bacilli, particularly Pseudomonas aeruginosa.

Chlorophenesin Pharmacology

Colistin is a polymyxin antibiotic agent. Polymyxins are cationic polypeptides that disrupt the bacterial cell membrane through a detergentlike mechanism. With the development of less toxic agents, such as extended-spectrum penicillins and cephalosporins, parenteral polymyxin use was largely abandoned, except for the treatment of multidrug-resistant pulmonary infections in patients with cystic fibrosis. More recently, however, the emergence of multidrug-resistant gram-negative bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii, and the lack of new antimicrobial agents have led to the revived use of the polymyxins.

Chlorophenesin Absorption

Very poor absorption from gastrointestinal tract.

Chlorophenesin side effects and Toxicity

Oral LD50 in rats is 5450 mg/kg. Overdosage with colistimethate can cause neuromuscular blockade characterized by paresthesia, lethargy, confusion, dizziness, ataxia, nystagmus, disorders of speech and apnea. Respiratory muscle paralysis may lead to apnea, respiratory arrest and death.

Chlorophenesin Patient Information

No information avaliable

Chlorophenesin Organisms Affected

Gram-negative bacilli