Codeine
Codeine Brand names, Codeine Analogs
Codeine Brand Names Mixture
- No information avaliable
Codeine Chemical_Formula
C18H21NO3
Codeine RX_link
http://www.rxlist.com/cgi/generic/codphos.htm
Codeine fda sheet
Codeine msds (material safety sheet)
Codeine Synthesis Reference
Goto, Yamamoto, Proc. Japan Acad. 30, 769 (1954)
Codeine Molecular Weight
299.364 g/mol
Codeine Melting Point
154 - 156 oC
Codeine H2O Solubility
<0.1 g/100 mL
Codeine State
solid
Codeine LogP
1.809
Codeine Dosage Forms
Oral solution; Tablet
Codeine Indication
For treatment and management of pain (Systemic), also used as an Antidiarrheal and as a cough suppressant.
Codeine Pharmacology
Codeine, an opiate agonist in the CNS, is similar to other phenanthrene derivatives such as morphine. Codeine, in combination with guaifenesin or iodinated glycerol, is used as a cough suppressant and, as a single agent or in combination with acetaminophen or other products, is used for pain control and as an antidiarrheal agent.
Codeine Absorption
well absorbed
Codeine side effects and Toxicity
Respiratory depression, sedation and miosis and common symptoms of overdose. Other symptoms include nausea, vomiting, skeletal muscle flaccidity, bradycardia, hypotension, and cool, clammy skin. Apnea and death may ensue
Codeine Patient Information
Codeine may impair the mental and/or physical abilities required for the performance of potentially hazardous tasks, s.c. as driving a car or operating machinery. Codeine in combination with other narcotic analgesics, phenothiazines, sedative hypnotics, and alcohol has additive depressant effects.
Codeine Organisms Affected
Humans and other mammals
