Norcodeine, N-Methyl
Brand names,
Norcodeine, N-Methyl
Analogs
Norcodeine, N-Methyl
Brand Names Mixture
Norcodeine, N-Methyl
Chemical_Formula
C18H21NO3
Norcodeine, N-Methyl
RX_link
http://www.rxlist.com/cgi/generic/codphos.htm
Norcodeine, N-Methyl
fda sheet
Norcodeine, N-Methyl
msds (material safety sheet)
Norcodeine, N-Methyl
Synthesis Reference
Goto, Yamamoto, Proc. Japan Acad. 30, 769 (1954)
Norcodeine, N-Methyl
Molecular Weight
299.364 g/mol
Norcodeine, N-Methyl
Melting Point
154 - 156 oC
Norcodeine, N-Methyl
H2O Solubility
<0.1 g/100 mL
Norcodeine, N-Methyl
State
solid
Norcodeine, N-Methyl
LogP
1.809
Norcodeine, N-Methyl
Dosage Forms
Oral solution; Tablet
Norcodeine, N-Methyl
Indication
For treatment and management of pain (Systemic), also used as an Antidiarrheal and as a cough suppressant.
Norcodeine, N-Methyl
Pharmacology
Codeine, an opiate agonist in the CNS, is similar to other phenanthrene derivatives such as morphine. Codeine, in combination with guaifenesin or iodinated glycerol, is used as a cough suppressant and, as a single agent or in combination with acetaminophen or other products, is used for pain control and as an antidiarrheal agent.
Norcodeine, N-Methyl
Absorption
well absorbed
Norcodeine, N-Methyl
side effects and Toxicity
Respiratory depression, sedation and miosis and common symptoms of overdose. Other symptoms include nausea, vomiting, skeletal muscle flaccidity, bradycardia, hypotension, and cool, clammy skin. Apnea and death may ensue
Norcodeine, N-Methyl
Patient Information
Codeine may impair the mental and/or physical abilities required for the performance of potentially hazardous
tasks, s.c. as driving a car or operating machinery. Codeine in combination with other narcotic analgesics,
phenothiazines, sedative hypnotics, and alcohol has additive depressant effects.
Norcodeine, N-Methyl
Organisms Affected
Humans and other mammals