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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C18H21NO3
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RX_link
http://www.rxlist.com/cgi/generic/codphos.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Goto, Yamamoto, Proc. Japan Acad. 30, 769 (1954)
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Molecular Weight
299.364 g/mol
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Melting Point
154 - 156 oC
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H2O Solubility
<0.1 g/100 mL
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State
solid
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LogP
1.809
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Dosage Forms
Oral solution; Tablet
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Indication
For treatment and management of pain (Systemic), also used as an Antidiarrheal and as a cough suppressant.
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Pharmacology
Codeine, an opiate agonist in the CNS, is similar to other phenanthrene derivatives such as morphine. Codeine, in combination with guaifenesin or iodinated glycerol, is used as a cough suppressant and, as a single agent or in combination with acetaminophen or other products, is used for pain control and as an antidiarrheal agent.
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Absorption
well absorbed
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side effects and Toxicity
Respiratory depression, sedation and miosis and common symptoms of overdose. Other symptoms include nausea, vomiting, skeletal muscle flaccidity, bradycardia, hypotension, and cool, clammy skin. Apnea and death may ensue
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Patient Information
Codeine may impair the mental and/or physical abilities required for the performance of potentially hazardous
tasks, s.c. as driving a car or operating machinery. Codeine in combination with other narcotic analgesics,
phenothiazines, sedative hypnotics, and alcohol has additive depressant effects.
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Organisms Affected
Humans and other mammals