Codeine anhydrous
Brand names,
Codeine anhydrous
Analogs
Codeine anhydrous
Brand Names Mixture
Codeine anhydrous
Chemical_Formula
C18H21NO3
Codeine anhydrous
RX_link
http://www.rxlist.com/cgi/generic/codphos.htm
Codeine anhydrous
fda sheet
Codeine anhydrous
msds (material safety sheet)
Codeine anhydrous
Synthesis Reference
Goto, Yamamoto, Proc. Japan Acad. 30, 769 (1954)
Codeine anhydrous
Molecular Weight
299.364 g/mol
Codeine anhydrous
Melting Point
154 - 156 oC
Codeine anhydrous
H2O Solubility
<0.1 g/100 mL
Codeine anhydrous
State
solid
Codeine anhydrous
LogP
1.809
Codeine anhydrous
Dosage Forms
Oral solution; Tablet
Codeine anhydrous
Indication
For treatment and management of pain (Systemic), also used as an Antidiarrheal and as a cough suppressant.
Codeine anhydrous
Pharmacology
Codeine, an opiate agonist in the CNS, is similar to other phenanthrene derivatives such as morphine. Codeine, in combination with guaifenesin or iodinated glycerol, is used as a cough suppressant and, as a single agent or in combination with acetaminophen or other products, is used for pain control and as an antidiarrheal agent.
Codeine anhydrous
Absorption
well absorbed
Codeine anhydrous
side effects and Toxicity
Respiratory depression, sedation and miosis and common symptoms of overdose. Other symptoms include nausea, vomiting, skeletal muscle flaccidity, bradycardia, hypotension, and cool, clammy skin. Apnea and death may ensue
Codeine anhydrous
Patient Information
Codeine may impair the mental and/or physical abilities required for the performance of potentially hazardous
tasks, s.c. as driving a car or operating machinery. Codeine in combination with other narcotic analgesics,
phenothiazines, sedative hypnotics, and alcohol has additive depressant effects.
Codeine anhydrous
Organisms Affected
Humans and other mammals