Biperidine Hydrochloride

Biperidine Hydrochloride Brand names, Biperidine Hydrochloride Analogs

Biperidine Hydrochloride Brand Names Mixture

No information avaliable

Biperidine Hydrochloride Chemical_Formula

C₂₁H₂₉NO

Biperidine Hydrochloride RX_link

http://www.rxlist.com/cgi/generic2/biperiden.htm

Biperidine Hydrochloride fda sheet

Biperidine Hydrochloride msds (material safety sheet)

Biperidine Hydrochloride Synthesis Reference

No information avaliable

Biperidine Hydrochloride Molecular Weight

311.461 g/mol

Biperidine Hydrochloride Melting Point

114 ^oC

Biperidine Hydrochloride H₂O Solubility

25.1 mg/L

Biperidine Hydrochloride State

Solid

Biperidine Hydrochloride LogP

3.85

Biperidine Hydrochloride Dosage Forms

Tablet

Biperidine Hydrochloride Indication

For use as an adjunct in the therapy of all forms of parkinsonism and control of extrapyramidal disorders secondary to neuroleptic drug therapy.

Biperidine Hydrochloride Pharmacology

Biperiden is a weak peripheral anticholinergic agent. It has, therefore, some antisecretory, antispasmodic and mydriatic effects. In addition, biperiden possesses nicotinolytic activity. The parenteral form of biperiden is an effective and reliable agent for the treatment of acute episodes of extrapyramidal disturbances sometimes seen during treatment with neuroleptic agents. Akathisia, akinesia, dyskinetic tremors, rigor, oculogyric crisis, spasmodic torticollis, and profuse sweating are markedly reduced or eliminated. With parenteral biperiden, these drug-induced disturbances are rapidly brought under control.

Biperidine Hydrochloride Absorption

87% bioavailability

Biperidine Hydrochloride side effects and Toxicity

LD₅₀=760 mg/kg (Orally in rats). Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.

Biperidine Hydrochloride Patient Information