Biperidene Hydrochloride

Biperidene Hydrochloride Brand names, Biperidene Hydrochloride Analogs

Biperidene Hydrochloride Brand Names Mixture

No information avaliable

Biperidene Hydrochloride Chemical_Formula

C₂₁H₂₉NO

Biperidene Hydrochloride RX_link

http://www.rxlist.com/cgi/generic2/biperiden.htm

Biperidene Hydrochloride fda sheet

Biperidene Hydrochloride msds (material safety sheet)

Biperidene Hydrochloride Synthesis Reference

No information avaliable

Biperidene Hydrochloride Molecular Weight

311.461 g/mol

Biperidene Hydrochloride Melting Point

114 ^oC

Biperidene Hydrochloride H₂O Solubility

25.1 mg/L

Biperidene Hydrochloride State

Solid

Biperidene Hydrochloride LogP

3.85

Biperidene Hydrochloride Dosage Forms

Tablet

Biperidene Hydrochloride Indication

For use as an adjunct in the therapy of all forms of parkinsonism and control of extrapyramidal disorders secondary to neuroleptic drug therapy.

Biperidene Hydrochloride Pharmacology

Biperiden is a weak peripheral anticholinergic agent. It has, therefore, some antisecretory, antispasmodic and mydriatic effects. In addition, biperiden possesses nicotinolytic activity. The parenteral form of biperiden is an effective and reliable agent for the treatment of acute episodes of extrapyramidal disturbances sometimes seen during treatment with neuroleptic agents. Akathisia, akinesia, dyskinetic tremors, rigor, oculogyric crisis, spasmodic torticollis, and profuse sweating are markedly reduced or eliminated. With parenteral biperiden, these drug-induced disturbances are rapidly brought under control.

Biperidene Hydrochloride Absorption

87% bioavailability

Biperidene Hydrochloride side effects and Toxicity

LD₅₀=760 mg/kg (Orally in rats). Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.

Biperidene Hydrochloride Patient Information