Biperiden Hydrochloride

Biperiden Hydrochloride Brand names, Biperiden Hydrochloride Analogs

Biperiden Hydrochloride Brand Names Mixture

No information avaliable

Biperiden Hydrochloride Chemical_Formula

C₂₁H₂₉NO

Biperiden Hydrochloride RX_link

http://www.rxlist.com/cgi/generic2/biperiden.htm

Biperiden Hydrochloride fda sheet

Biperiden Hydrochloride msds (material safety sheet)

Biperiden Hydrochloride Synthesis Reference

No information avaliable

Biperiden Hydrochloride Molecular Weight

311.461 g/mol

Biperiden Hydrochloride Melting Point

114 ^oC

Biperiden Hydrochloride H₂O Solubility

25.1 mg/L

Biperiden Hydrochloride State

Solid

Biperiden Hydrochloride LogP

3.85

Biperiden Hydrochloride Dosage Forms

Tablet

Biperiden Hydrochloride Indication

For use as an adjunct in the therapy of all forms of parkinsonism and control of extrapyramidal disorders secondary to neuroleptic drug therapy.

Biperiden Hydrochloride Pharmacology

Biperiden is a weak peripheral anticholinergic agent. It has, therefore, some antisecretory, antispasmodic and mydriatic effects. In addition, biperiden possesses nicotinolytic activity. The parenteral form of biperiden is an effective and reliable agent for the treatment of acute episodes of extrapyramidal disturbances sometimes seen during treatment with neuroleptic agents. Akathisia, akinesia, dyskinetic tremors, rigor, oculogyric crisis, spasmodic torticollis, and profuse sweating are markedly reduced or eliminated. With parenteral biperiden, these drug-induced disturbances are rapidly brought under control.

Biperiden Hydrochloride Absorption

87% bioavailability

Biperiden Hydrochloride side effects and Toxicity

LD₅₀=760 mg/kg (Orally in rats). Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.

Biperiden Hydrochloride Patient Information