Akinophyl

Akinophyl Brand names, Akinophyl Analogs

Akinophyl Brand Names Mixture

No information avaliable

Akinophyl Chemical_Formula

C₂₁H₂₉NO

Akinophyl RX_link

http://www.rxlist.com/cgi/generic2/biperiden.htm

Akinophyl fda sheet

Akinophyl msds (material safety sheet)

Akinophyl Synthesis Reference

No information avaliable

Akinophyl Molecular Weight

311.461 g/mol

Akinophyl Melting Point

114 ^oC

Akinophyl H₂O Solubility

25.1 mg/L

Akinophyl State

Solid

Akinophyl LogP

3.85

Akinophyl Dosage Forms

Tablet

Akinophyl Indication

For use as an adjunct in the therapy of all forms of parkinsonism and control of extrapyramidal disorders secondary to neuroleptic drug therapy.

Akinophyl Pharmacology

Biperiden is a weak peripheral anticholinergic agent. It has, therefore, some antisecretory, antispasmodic and mydriatic effects. In addition, biperiden possesses nicotinolytic activity. The parenteral form of biperiden is an effective and reliable agent for the treatment of acute episodes of extrapyramidal disturbances sometimes seen during treatment with neuroleptic agents. Akathisia, akinesia, dyskinetic tremors, rigor, oculogyric crisis, spasmodic torticollis, and profuse sweating are markedly reduced or eliminated. With parenteral biperiden, these drug-induced disturbances are rapidly brought under control.

Akinophyl Absorption

87% bioavailability

Akinophyl side effects and Toxicity

LD₅₀=760 mg/kg (Orally in rats). Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.

Akinophyl Patient Information