Aminoglutethimide en es it fr

Aminoglutethimide Brand names, Aminoglutethimide Analogs

Aminoglutethimide Brand Names Mixture

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Aminoglutethimide Chemical_Formula


Aminoglutethimide RX_link

Aminoglutethimide fda sheet

Aminoglutethimide FDA

Aminoglutethimide msds (material safety sheet)

Aminoglutethimide Synthesis Reference

Hoffmann, Urech, U.S. pat. 2,848,455 (1958 to Ciba)

Aminoglutethimide Molecular Weight

232.278 g/mol

Aminoglutethimide Melting Point

149-150 oC

Aminoglutethimide H2O Solubility

Practically insoluble in water

Aminoglutethimide State


Aminoglutethimide LogP


Aminoglutethimide Dosage Forms

Tablet (250 mg)

Aminoglutethimide Indication

For the suppression of adrenal function in selected patients with Cushing's syndrome, malignant neoplasm of the female breast, and carcinoma in situ of the breast.

Aminoglutethimide Pharmacology

Aminoglutethimide inhibits the enzymatic conversion of cholesterol to D5-pregnenolone, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens.

Aminoglutethimide Absorption

Rapidly and completely absorbed from gastrointestinal tract. The bioavailability of tablets is equivalent to equal doses given as a solution.

Aminoglutethimide side effects and Toxicity

Oral LD50s (mg/kg): rats, 1800; dogs, >100. Intravenous LD50s (mg/kg): rats, 156; dogs, >100. Symptoms of overdose include respiratory depression, hypoventilation, hypotension, hypovolemic shock due to dehydration, somnolence, lethargy, coma, ataxia, dizziness, fatigue, nausea, and vomiting.

Aminoglutethimide Patient Information

Aminoglutethimide Organisms Affected

Humans and other mammals