Glutethimide
Glutethimide Brand names, Glutethimide Analogs
Glutethimide Brand Names Mixture
- No information avaliable
Glutethimide Chemical_Formula
C13H16N2O2
Glutethimide RX_link
http://www.rxlist.com/cgi/generic3/cytadren.htm
Glutethimide fda sheet
Glutethimide msds (material safety sheet)
Glutethimide Synthesis Reference
Hoffmann, Urech, U.S. pat. 2,848,455 (1958 to Ciba)
Glutethimide Molecular Weight
232.278 g/mol
Glutethimide Melting Point
149-150 oC
Glutethimide H2O Solubility
Practically insoluble in water
Glutethimide State
Solid
Glutethimide LogP
2.029
Glutethimide Dosage Forms
Tablet (250 mg)
Glutethimide Indication
For the suppression of adrenal function in selected patients with Cushing's syndrome, malignant neoplasm of the female breast, and carcinoma in situ of the breast.
Glutethimide Pharmacology
Aminoglutethimide inhibits the enzymatic conversion of cholesterol to D5-pregnenolone, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens.
Glutethimide Absorption
Rapidly and completely absorbed from gastrointestinal tract. The bioavailability of tablets is equivalent to equal doses given as a solution.
Glutethimide side effects and Toxicity
Oral LD50s (mg/kg): rats, 1800; dogs, >100. Intravenous LD50s (mg/kg): rats, 156; dogs, >100. Symptoms of overdose include respiratory depression, hypoventilation, hypotension, hypovolemic shock due to dehydration, somnolence, lethargy, coma, ataxia, dizziness, fatigue, nausea, and vomiting.
Glutethimide Patient Information
Glutethimide Organisms Affected
Humans and other mammals
