Glutethimide en es it fr

Glutethimide Brand names, Glutethimide Analogs

Glutethimide Brand Names Mixture

  • No information avaliable

Glutethimide Chemical_Formula


Glutethimide RX_link

Glutethimide fda sheet

Glutethimide FDA

Glutethimide msds (material safety sheet)

Glutethimide Synthesis Reference

Hoffmann, Urech, U.S. pat. 2,848,455 (1958 to Ciba)

Glutethimide Molecular Weight

232.278 g/mol

Glutethimide Melting Point

149-150 oC

Glutethimide H2O Solubility

Practically insoluble in water

Glutethimide State


Glutethimide LogP


Glutethimide Dosage Forms

Tablet (250 mg)

Glutethimide Indication

For the suppression of adrenal function in selected patients with Cushing's syndrome, malignant neoplasm of the female breast, and carcinoma in situ of the breast.

Glutethimide Pharmacology

Aminoglutethimide inhibits the enzymatic conversion of cholesterol to D5-pregnenolone, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens.

Glutethimide Absorption

Rapidly and completely absorbed from gastrointestinal tract. The bioavailability of tablets is equivalent to equal doses given as a solution.

Glutethimide side effects and Toxicity

Oral LD50s (mg/kg): rats, 1800; dogs, >100. Intravenous LD50s (mg/kg): rats, 156; dogs, >100. Symptoms of overdose include respiratory depression, hypoventilation, hypotension, hypovolemic shock due to dehydration, somnolence, lethargy, coma, ataxia, dizziness, fatigue, nausea, and vomiting.

Glutethimide Patient Information

Glutethimide Organisms Affected

Humans and other mammals