Cytadren
Cytadren Brand names, Cytadren Analogs
Cytadren Brand Names Mixture
- No information avaliable
Cytadren Chemical_Formula
C13H16N2O2
Cytadren RX_link
http://www.rxlist.com/cgi/generic3/cytadren.htm
Cytadren fda sheet
Cytadren msds (material safety sheet)
Cytadren Synthesis Reference
Hoffmann, Urech, U.S. pat. 2,848,455 (1958 to Ciba)
Cytadren Molecular Weight
232.278 g/mol
Cytadren Melting Point
149-150 oC
Cytadren H2O Solubility
Practically insoluble in water
Cytadren State
Solid
Cytadren LogP
2.029
Cytadren Dosage Forms
Tablet (250 mg)
Cytadren Indication
For the suppression of adrenal function in selected patients with Cushing's syndrome, malignant neoplasm of the female breast, and carcinoma in situ of the breast.
Cytadren Pharmacology
Aminoglutethimide inhibits the enzymatic conversion of cholesterol to D5-pregnenolone, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens.
Cytadren Absorption
Rapidly and completely absorbed from gastrointestinal tract. The bioavailability of tablets is equivalent to equal doses given as a solution.
Cytadren side effects and Toxicity
Oral LD50s (mg/kg): rats, 1800; dogs, >100. Intravenous LD50s (mg/kg): rats, 156; dogs, >100. Symptoms of overdose include respiratory depression, hypoventilation, hypotension, hypovolemic shock due to dehydration, somnolence, lethargy, coma, ataxia, dizziness, fatigue, nausea, and vomiting.
Cytadren Patient Information
Cytadren Organisms Affected
Humans and other mammals
