Elipten
Elipten Brand names, Elipten Analogs
Elipten Brand Names Mixture
- No information avaliable
Elipten Chemical_Formula
C13H16N2O2
Elipten RX_link
http://www.rxlist.com/cgi/generic3/cytadren.htm
Elipten fda sheet
Elipten msds (material safety sheet)
Elipten Synthesis Reference
Hoffmann, Urech, U.S. pat. 2,848,455 (1958 to Ciba)
Elipten Molecular Weight
232.278 g/mol
Elipten Melting Point
149-150 oC
Elipten H2O Solubility
Practically insoluble in water
Elipten State
Solid
Elipten LogP
2.029
Elipten Dosage Forms
Tablet (250 mg)
Elipten Indication
For the suppression of adrenal function in selected patients with Cushing's syndrome, malignant neoplasm of the female breast, and carcinoma in situ of the breast.
Elipten Pharmacology
Aminoglutethimide inhibits the enzymatic conversion of cholesterol to D5-pregnenolone, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens.
Elipten Absorption
Rapidly and completely absorbed from gastrointestinal tract. The bioavailability of tablets is equivalent to equal doses given as a solution.
Elipten side effects and Toxicity
Oral LD50s (mg/kg): rats, 1800; dogs, >100. Intravenous LD50s (mg/kg): rats, 156; dogs, >100. Symptoms of overdose include respiratory depression, hypoventilation, hypotension, hypovolemic shock due to dehydration, somnolence, lethargy, coma, ataxia, dizziness, fatigue, nausea, and vomiting.
Elipten Patient Information
Elipten Organisms Affected
Humans and other mammals
