P-Aminoglutethimide

P-Aminoglutethimide Brand names, P-Aminoglutethimide Analogs

P-Aminoglutethimide Brand Names Mixture

No information avaliable

P-Aminoglutethimide Chemical_Formula

C₁₃H₁₆N₂O₂

P-Aminoglutethimide RX_link

http://www.rxlist.com/cgi/generic3/cytadren.htm

P-Aminoglutethimide fda sheet

P-Aminoglutethimide FDA

P-Aminoglutethimide msds (material safety sheet)

P-Aminoglutethimide Synthesis Reference

Hoffmann, Urech, U.S. pat. 2,848,455 (1958 to Ciba)

P-Aminoglutethimide Molecular Weight

232.278 g/mol

P-Aminoglutethimide Melting Point

149-150 ^oC

P-Aminoglutethimide H₂O Solubility

Practically insoluble in water

P-Aminoglutethimide State

Solid

P-Aminoglutethimide LogP

2.029

P-Aminoglutethimide Dosage Forms

Tablet (250 mg)

P-Aminoglutethimide Indication

For the suppression of adrenal function in selected patients with Cushing's syndrome, malignant neoplasm of the female breast, and carcinoma in situ of the breast.

P-Aminoglutethimide Pharmacology

Aminoglutethimide inhibits the enzymatic conversion of cholesterol to D5-pregnenolone, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens.

P-Aminoglutethimide Absorption

Rapidly and completely absorbed from gastrointestinal tract. The bioavailability of tablets is equivalent to equal doses given as a solution.

P-Aminoglutethimide side effects and Toxicity

Oral LD50s (mg/kg): rats, 1800; dogs, >100. Intravenous LD50s (mg/kg): rats, 156; dogs, >100. Symptoms of overdose include respiratory depression, hypoventilation, hypotension, hypovolemic shock due to dehydration, somnolence, lethargy, coma, ataxia, dizziness, fatigue, nausea, and vomiting.

P-Aminoglutethimide Patient Information

P-Aminoglutethimide Organisms Affected

Humans and other mammals