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Doriden Brand names, Doriden Analogs

Doriden Brand Names Mixture

  • No information avaliable

Doriden Chemical_Formula


Doriden RX_link

Doriden fda sheet

Doriden FDA

Doriden msds (material safety sheet)

Doriden Synthesis Reference

Hoffmann, Urech, U.S. pat. 2,848,455 (1958 to Ciba)

Doriden Molecular Weight

232.278 g/mol

Doriden Melting Point

149-150 oC

Doriden H2O Solubility

Practically insoluble in water

Doriden State


Doriden LogP


Doriden Dosage Forms

Tablet (250 mg)

Doriden Indication

For the suppression of adrenal function in selected patients with Cushing's syndrome, malignant neoplasm of the female breast, and carcinoma in situ of the breast.

Doriden Pharmacology

Aminoglutethimide inhibits the enzymatic conversion of cholesterol to D5-pregnenolone, resulting in a decrease in the production of adrenal glucocorticoids, mineralocorticoids, estrogens, and androgens.

Doriden Absorption

Rapidly and completely absorbed from gastrointestinal tract. The bioavailability of tablets is equivalent to equal doses given as a solution.

Doriden side effects and Toxicity

Oral LD50s (mg/kg): rats, 1800; dogs, >100. Intravenous LD50s (mg/kg): rats, 156; dogs, >100. Symptoms of overdose include respiratory depression, hypoventilation, hypotension, hypovolemic shock due to dehydration, somnolence, lethargy, coma, ataxia, dizziness, fatigue, nausea, and vomiting.

Doriden Patient Information

Doriden Organisms Affected

Humans and other mammals