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Altretamine Brand names, Altretamine Analogs

Altretamine Brand Names Mixture

  • No information avaliable

Altretamine Chemical_Formula


Altretamine RX_link

Altretamine fda sheet

Altretamine msds (material safety sheet)

Altretamine Synthesis Reference

No information avaliable

Altretamine Molecular Weight

210.28 g/mol

Altretamine Melting Point

172-174 oC

Altretamine H2O Solubility

91 mg/L

Altretamine State


Altretamine LogP


Altretamine Dosage Forms


Altretamine Indication

For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.

Altretamine Pharmacology

Altretamine is a novel antineoplastic agent. The precise mechanism by which altretamine exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine resembles the alkylating agent triethylenemelamine, yet in vitro tests for alkylating activity of altretamine and its metabolitics have been negative. Altretamine has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement of cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, in vitro and in vivo, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown.

Altretamine Absorption

No information avaliable

Altretamine side effects and Toxicity

No information avaliable

Altretamine Patient Information

No information avaliable

Altretamine Organisms Affected

Humans and other mammals