Altretamine
Altretamine Brand names, Altretamine Analogs
Altretamine Brand Names Mixture
- No information avaliable
Altretamine Chemical_Formula
C9H18N6
Altretamine RX_link
http://www.rxlist.com/cgi/generic/altretamine.htm
Altretamine fda sheet
Altretamine msds (material safety sheet)
Altretamine Synthesis Reference
No information avaliable
Altretamine Molecular Weight
210.28 g/mol
Altretamine Melting Point
172-174 oC
Altretamine H2O Solubility
91 mg/L
Altretamine State
Solid
Altretamine LogP
1.566
Altretamine Dosage Forms
Capsule
Altretamine Indication
For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.
Altretamine Pharmacology
Altretamine is a novel antineoplastic agent. The precise mechanism by which altretamine exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine resembles the alkylating agent triethylenemelamine, yet in vitro tests for alkylating activity of altretamine and its metabolitics have been negative. Altretamine has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement of cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, in vitro and in vivo, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown.
Altretamine Absorption
No information avaliable
Altretamine side effects and Toxicity
No information avaliable
Altretamine Patient Information
No information avaliable
Altretamine Organisms Affected
Humans and other mammals
