Hexastat
Hexastat Brand names, Hexastat Analogs
Hexastat Brand Names Mixture
- No information avaliable
Hexastat Chemical_Formula
C9H18N6
Hexastat RX_link
http://www.rxlist.com/cgi/generic/altretamine.htm
Hexastat fda sheet
Hexastat msds (material safety sheet)
Hexastat Synthesis Reference
No information avaliable
Hexastat Molecular Weight
210.28 g/mol
Hexastat Melting Point
172-174 oC
Hexastat H2O Solubility
91 mg/L
Hexastat State
Solid
Hexastat LogP
1.566
Hexastat Dosage Forms
Capsule
Hexastat Indication
For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.
Hexastat Pharmacology
Altretamine is a novel antineoplastic agent. The precise mechanism by which altretamine exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine resembles the alkylating agent triethylenemelamine, yet in vitro tests for alkylating activity of altretamine and its metabolitics have been negative. Altretamine has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement of cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, in vitro and in vivo, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown.
Hexastat Absorption
No information avaliable
Hexastat side effects and Toxicity
No information avaliable
Hexastat Patient Information
No information avaliable
Hexastat Organisms Affected
Humans and other mammals
