PharmacyCodes



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HMM Brand names, HMM Analogs

HMM Brand Names Mixture

  • No information avaliable

HMM Chemical_Formula

C9H18N6

HMM RX_link

http://www.rxlist.com/cgi/generic/altretamine.htm

HMM fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=104

HMM msds (material safety sheet)

HMM Synthesis Reference

No information avaliable

HMM Molecular Weight

210.28 g/mol

HMM Melting Point

172-174 oC

HMM H2O Solubility

91 mg/L

HMM State

Solid

HMM LogP

1.566

HMM Dosage Forms

Capsule

HMM Indication

For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.

HMM Pharmacology

Altretamine is a novel antineoplastic agent. The precise mechanism by which altretamine exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine resembles the alkylating agent triethylenemelamine, yet in vitro tests for alkylating activity of altretamine and its metabolitics have been negative. Altretamine has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement of cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, in vitro and in vivo, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown.

HMM Absorption

No information avaliable

HMM side effects and Toxicity

No information avaliable

HMM Patient Information

No information avaliable

HMM Organisms Affected

Humans and other mammals