Hemel
Hemel Brand names, Hemel Analogs
Hemel Brand Names Mixture
- No information avaliable
Hemel Chemical_Formula
C9H18N6
Hemel RX_link
http://www.rxlist.com/cgi/generic/altretamine.htm
Hemel fda sheet
Hemel msds (material safety sheet)
Hemel Synthesis Reference
No information avaliable
Hemel Molecular Weight
210.28 g/mol
Hemel Melting Point
172-174 oC
Hemel H2O Solubility
91 mg/L
Hemel State
Solid
Hemel LogP
1.566
Hemel Dosage Forms
Capsule
Hemel Indication
For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.
Hemel Pharmacology
Altretamine is a novel antineoplastic agent. The precise mechanism by which altretamine exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine resembles the alkylating agent triethylenemelamine, yet in vitro tests for alkylating activity of altretamine and its metabolitics have been negative. Altretamine has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement of cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, in vitro and in vivo, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown.
Hemel Absorption
No information avaliable
Hemel side effects and Toxicity
No information avaliable
Hemel Patient Information
No information avaliable
Hemel Organisms Affected
Humans and other mammals
