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HTM Brand names, HTM Analogs

HTM Brand Names Mixture

  • No information avaliable

HTM Chemical_Formula


HTM RX_link

HTM fda sheet

HTM msds (material safety sheet)

HTM Synthesis Reference

No information avaliable

HTM Molecular Weight

210.28 g/mol

HTM Melting Point

172-174 oC

HTM H2O Solubility

91 mg/L

HTM State




HTM Dosage Forms


HTM Indication

For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.

HTM Pharmacology

Altretamine is a novel antineoplastic agent. The precise mechanism by which altretamine exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine resembles the alkylating agent triethylenemelamine, yet in vitro tests for alkylating activity of altretamine and its metabolitics have been negative. Altretamine has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement of cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, in vitro and in vivo, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown.

HTM Absorption

No information avaliable

HTM side effects and Toxicity

No information avaliable

HTM Patient Information

No information avaliable

HTM Organisms Affected

Humans and other mammals