HXM
HXM Brand names, HXM Analogs
HXM Brand Names Mixture
- No information avaliable
HXM Chemical_Formula
C9H18N6
HXM RX_link
http://www.rxlist.com/cgi/generic/altretamine.htm
HXM fda sheet
HXM msds (material safety sheet)
HXM Synthesis Reference
No information avaliable
HXM Molecular Weight
210.28 g/mol
HXM Melting Point
172-174 oC
HXM H2O Solubility
91 mg/L
HXM State
Solid
HXM LogP
1.566
HXM Dosage Forms
Capsule
HXM Indication
For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.
HXM Pharmacology
Altretamine is a novel antineoplastic agent. The precise mechanism by which altretamine exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine resembles the alkylating agent triethylenemelamine, yet in vitro tests for alkylating activity of altretamine and its metabolitics have been negative. Altretamine has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement of cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, in vitro and in vivo, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown.
HXM Absorption
No information avaliable
HXM side effects and Toxicity
No information avaliable
HXM Patient Information
No information avaliable
HXM Organisms Affected
Humans and other mammals
