HEXAMETHYLMELAMINE
HEXAMETHYLMELAMINE Brand names, HEXAMETHYLMELAMINE Analogs
HEXAMETHYLMELAMINE Brand Names Mixture
- No information avaliable
HEXAMETHYLMELAMINE Chemical_Formula
C9H18N6
HEXAMETHYLMELAMINE RX_link
http://www.rxlist.com/cgi/generic/altretamine.htm
HEXAMETHYLMELAMINE fda sheet
HEXAMETHYLMELAMINE msds (material safety sheet)
HEXAMETHYLMELAMINE Synthesis Reference
No information avaliable
HEXAMETHYLMELAMINE Molecular Weight
210.28 g/mol
HEXAMETHYLMELAMINE Melting Point
172-174 oC
HEXAMETHYLMELAMINE H2O Solubility
91 mg/L
HEXAMETHYLMELAMINE State
Solid
HEXAMETHYLMELAMINE LogP
1.566
HEXAMETHYLMELAMINE Dosage Forms
Capsule
HEXAMETHYLMELAMINE Indication
For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.
HEXAMETHYLMELAMINE Pharmacology
Altretamine is a novel antineoplastic agent. The precise mechanism by which altretamine exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine resembles the alkylating agent triethylenemelamine, yet in vitro tests for alkylating activity of altretamine and its metabolitics have been negative. Altretamine has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement of cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, in vitro and in vivo, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown.
HEXAMETHYLMELAMINE Absorption
No information avaliable
HEXAMETHYLMELAMINE side effects and Toxicity
No information avaliable
HEXAMETHYLMELAMINE Patient Information
No information avaliable
HEXAMETHYLMELAMINE Organisms Affected
Humans and other mammals
