Hexalen
Hexalen Brand names, Hexalen Analogs
Hexalen Brand Names Mixture
- No information avaliable
Hexalen Chemical_Formula
C9H18N6
Hexalen RX_link
http://www.rxlist.com/cgi/generic/altretamine.htm
Hexalen fda sheet
Hexalen msds (material safety sheet)
Hexalen Synthesis Reference
No information avaliable
Hexalen Molecular Weight
210.28 g/mol
Hexalen Melting Point
172-174 oC
Hexalen H2O Solubility
91 mg/L
Hexalen State
Solid
Hexalen LogP
1.566
Hexalen Dosage Forms
Capsule
Hexalen Indication
For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.
Hexalen Pharmacology
Altretamine is a novel antineoplastic agent. The precise mechanism by which altretamine exerts its cytotoxic effect is unknown, although a number of theoretical possibilities have been studied. Structurally, altretamine resembles the alkylating agent triethylenemelamine, yet in vitro tests for alkylating activity of altretamine and its metabolitics have been negative. Altretamine has been demonstrated to be efficacious for certain ovarian tumors resistant to classical alkylating agents. Metabolism of altretamine is a requirement of cytotoxicity. Synthetic monohydroxymethylmelamines, and products of altretamine metabolism, in vitro and in vivo, can form covalent adducts with tissue macromolecules including DNA, but the relevance of these reactions to antitumor activity is unknown.
Hexalen Absorption
No information avaliable
Hexalen side effects and Toxicity
No information avaliable
Hexalen Patient Information
No information avaliable
Hexalen Organisms Affected
Humans and other mammals
