Alprostadil en es it fr

Alprostadil Brand names, Alprostadil Analogs

Alprostadil Brand Names Mixture

  • No information avaliable

Alprostadil Chemical_Formula


Alprostadil RX_link

Alprostadil fda sheet

Alprostadil FDA

Alprostadil msds (material safety sheet)

Alprostadil MSDS

Alprostadil Synthesis Reference

No information avaliable

Alprostadil Molecular Weight

354.481 g/mol

Alprostadil Melting Point

115 - 116 oC

Alprostadil H2O Solubility

26.7 mg/L

Alprostadil State


Alprostadil LogP


Alprostadil Dosage Forms

Liquid; Powder for solution; Solution; Suppository

Alprostadil Indication

For palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Also for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.

Alprostadil Pharmacology

Alprostadil (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation. In adult males, the vasodilatory effects of alprostadil on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arteriolar inflow and expansion of the lacunar spaces within the corpora. As the expanded corporal sinusoids are compressed against the tunica albuginea, venous outflow through the subtunical vessels is impeded and penile rigidity develops. This is referred to as the corporal veno-occlusive mechanism. In infants, the vasodilatory effects of alprostadil increase pulmonary or systemic blood flow.

Alprostadil Absorption

The absolute bioavailability of alprostadil has not been determined.

Alprostadil side effects and Toxicity

Oral, mouse: LD50 = 186 mg/kg; Oral, rat: LD50 = 228 mg/kg. Apnea, bradycardia, pyrexia, hypotension, and flushing may be signs of drug overdosage.

Alprostadil Patient Information

Alprostadil Organisms Affected

Humans and other mammals