Alprostadil
Alprostadil Brand names, Alprostadil Analogs
Alprostadil Brand Names Mixture
- No information avaliable
Alprostadil Chemical_Formula
C20H34O5
Alprostadil RX_link
http://www.rxlist.com/cgi/generic/alprostadil.htm
Alprostadil fda sheet
Alprostadil msds (material safety sheet)
Alprostadil Synthesis Reference
No information avaliable
Alprostadil Molecular Weight
354.481 g/mol
Alprostadil Melting Point
115 - 116 oC
Alprostadil H2O Solubility
26.7 mg/L
Alprostadil State
Solid
Alprostadil LogP
2.983
Alprostadil Dosage Forms
Liquid; Powder for solution; Solution; Suppository
Alprostadil Indication
For palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Also for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.
Alprostadil Pharmacology
Alprostadil (prostaglandin E1) is produced endogenously to relax vascular smooth muscle and cause vasodilation. In adult males, the vasodilatory effects of alprostadil on the cavernosal arteries and the trabecular smooth muscle of the corpora cavernosa result in rapid arteriolar inflow and expansion of the lacunar spaces within the corpora. As the expanded corporal sinusoids are compressed against the tunica albuginea, venous outflow through the subtunical vessels is impeded and penile rigidity develops. This is referred to as the corporal veno-occlusive mechanism. In infants, the vasodilatory effects of alprostadil increase pulmonary or systemic blood flow.
Alprostadil Absorption
The absolute bioavailability of alprostadil has not been determined.
Alprostadil side effects and Toxicity
Oral, mouse: LD50 = 186 mg/kg; Oral, rat: LD50 = 228 mg/kg. Apnea, bradycardia, pyrexia, hypotension, and flushing may be signs of drug overdosage.
Alprostadil Patient Information
Alprostadil Organisms Affected
Humans and other mammals
