Alpha medopa
Brand names,
Alpha medopa
Analogs
Alpha medopa
Brand Names Mixture
Alpha medopa
Chemical_Formula
C56H71N9O23S
Alpha medopa
RX_link
http://www.rxlist.com/cgi/generic4/mycamine.htm
Alpha medopa
fda sheet
Alpha medopa
msds (material safety sheet)
Alpha medopa
Synthesis Reference
No information avaliable
Alpha medopa
Molecular Weight
1270.28 g/mol
Alpha medopa
Melting Point
No information avaliable
Alpha medopa
H2O Solubility
Freely soluble as sodium salt (> 200mg/mL)
Alpha medopa
State
Solid
Alpha medopa
LogP
No information avaliable
Alpha medopa
Dosage Forms
Powder for solution (for injection)
Alpha medopa
Indication
For use in the treatment of patients with esophageal candidiasis and prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation.
Alpha medopa
Pharmacology
Formerly known as FK463, micafungin is a novel antifungal agent. It is a glucan synthesis inhibitor of the echinocandin structural class. The U.S. Food and Drug Administration approved micafungin in March 2005. Micafungin inhibits an enzyme essential for fungal cell-wall synthesis and is fungicidal (lethal) for Candida. Micafungin can be used concomitantly with a variety of other drugs, including the HIV protease inhibitor ritonavir and the transplant medications cyclosporine and tacrolimus.
Alpha medopa
Absorption
No information avaliable
Alpha medopa
side effects and Toxicity
Intravenous LD50 in rats is 125mg/kg. In dogs it is >200mg/kg. No cases of overdosage have been reported. Repeated daily doses up to 8 mg/kg (maximum total dose of 896 mg) in adult patients have been administered in clinical trials with no reported dose-limiting toxicity. The minimum lethal dose is 125 mg/kg in rats, equivalent to 8.1 times the recommended human clinical dose for esophageal candidiasis based on body surface area comparisons.
Alpha medopa
Patient Information
No information avaliable
Alpha medopa
Organisms Affected
Aspergillis, Candida and other fungi