Aldoril 15
Brand names,
Aldoril 15
Analogs
Aldoril 15
Brand Names Mixture
Aldoril 15
Chemical_Formula
C56H71N9O23S
Aldoril 15
RX_link
http://www.rxlist.com/cgi/generic4/mycamine.htm
Aldoril 15
fda sheet
Aldoril 15
msds (material safety sheet)
Aldoril 15
Synthesis Reference
No information avaliable
Aldoril 15
Molecular Weight
1270.28 g/mol
Aldoril 15
Melting Point
No information avaliable
Aldoril 15
H2O Solubility
Freely soluble as sodium salt (> 200mg/mL)
Aldoril 15
State
Solid
Aldoril 15
LogP
No information avaliable
Aldoril 15
Dosage Forms
Powder for solution (for injection)
Aldoril 15
Indication
For use in the treatment of patients with esophageal candidiasis and prophylaxis of Candida infections in patients undergoing hematopoietic stem cell transplantation.
Aldoril 15
Pharmacology
Formerly known as FK463, micafungin is a novel antifungal agent. It is a glucan synthesis inhibitor of the echinocandin structural class. The U.S. Food and Drug Administration approved micafungin in March 2005. Micafungin inhibits an enzyme essential for fungal cell-wall synthesis and is fungicidal (lethal) for Candida. Micafungin can be used concomitantly with a variety of other drugs, including the HIV protease inhibitor ritonavir and the transplant medications cyclosporine and tacrolimus.
Aldoril 15
Absorption
No information avaliable
Aldoril 15
side effects and Toxicity
Intravenous LD50 in rats is 125mg/kg. In dogs it is >200mg/kg. No cases of overdosage have been reported. Repeated daily doses up to 8 mg/kg (maximum total dose of 896 mg) in adult patients have been administered in clinical trials with no reported dose-limiting toxicity. The minimum lethal dose is 125 mg/kg in rats, equivalent to 8.1 times the recommended human clinical dose for esophageal candidiasis based on body surface area comparisons.
Aldoril 15
Patient Information
No information avaliable
Aldoril 15
Organisms Affected
Aspergillis, Candida and other fungi